Cefiderocol is a siderophore cephalosporin with a unique mechanism for penetrating efficiently into Gram-negative pathogens. Cefiderocol binds to free iron and is actively transported into bacterial cells through the outer membrane. This strategy allows cefiderocol to enter the space in-between the bacterial cell walls and disrupt cell wall synthesis.
In addition, cefiderocol is stable against nearly all beta-lactamases, including both the serine and metallo-carbapenemases.
Disk diffusion breakpoints for cefiderocol are available for Enterobacteriaceae, P. aeruginosa, A. baumannii and S. maltophilia.
Cefiderocol 30 μg disk (CE marked) is available by Liofilchem in two packaging formats:
50 disks – ref. 9266/1
250 disks – ref. 9266
